1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester → Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione

HRID 2194360노트

반응식

HRID 2194360 반응식
C[O:2][C:3]([CH:5]1[CH2:9][CH2:8][C:7](=[O:10])[N:6]1[CH2:11][C:12]#[N:13])=O>CO.O=[Pt]=O>[C:3]1(=[O:2])[NH:13][CH2:12][CH2:11][N:6]2[C:7](=[O:10])[CH2:8][CH:9]=[C:5]12

참가 물질

4

반응물 1

HCID 866498781-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

생성물 1

HCID 66867679Tetrahydro-pyrrolo[1,2-a]pyrazine-1,6-dione수율 63.1%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

1-Cyanomethyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester (1.1 g, 6.04 mmol) was dissolved in MeOH (30 ml) and hydrogenated over PtO2 (200 mg) at 20 psi for 24 hours. After filtration of the catalyst, the solvent was removed under vacuum and the residue triturated with iPrOH to afford the title compound as a white powder (580 mg, 62% yield).

후처리

  1. filtrationAfter filtration of the catalyst
  2. customthe solvent was removed under vacuum
  3. customthe residue triturated with iPrOH

출처 및 근거

ORD 기록
ord-a6b0968dc79a478b84af28cbee335112
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08334286B2

반응 노트

불러오는 중…