Hydrochloric Acid → 5-Bromo-4-methoxy-2-methylaniline
반응식
[Br:1][C:2]1[C:3]([O:13][CH3:14])=[CH:4][C:5]([CH3:12])=[C:6]([NH:8]C(=O)C)[CH:7]=1.Cl.C([O-])(O)=O.[Na+]>CO>[Br:1][C:2]1[C:3]([O:13][CH3:14])=[CH:4][C:5]([CH3:12])=[C:6]([CH:7]=1)[NH2:8]참가 물질
5
실험 절차
To a solution of N-(5-bromo-4-methoxy-2-methylphenyl)acetamide (108 g, 0.42 mol) in MeOH (400 mL) is added concentrated HCl (160 mL, 2 mol). After being heated at reflux overnight, the mixture is neutralized with aqueous NaHCO3, and extracted with EtOAc (1200 mL). The organic phase is dried and concentrated to afford the product (76 g, 84% yield). MS (m/z): 216.0 (M+H).
후처리
- temperatureAfter being heated
- temperatureat reflux overnight
- extractionextracted with EtOAc (1200 mL)
- customThe organic phase is dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-bd5eaa52db504658846adf2d4fe3e34a
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- USRE043878E1
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