Hydrochloric Acid → 2-nitro-5-piperazin-1-yl-benzoic Acid
반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:10](Cl)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.Cl>O>[N+:1]([C:4]1[CH:12]=[CH:11][C:10]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:9][C:5]=1[C:6]([OH:8])=[O:7])([O-:3])=[O:2]참가 물질
5
실험 절차
To the suspension of 50 g 2-nitro-5-chlorobenzoic acid in 750 ml water, 86 g of piperazine is added and the reaction mixture is heated at reflux temperature for 20 hours. The mixture is then neutralized with conc. hydrochloric acid and the precipitated crystalline material is filtered off and dried to obtain 62 g title compound (MH+: 252)
후처리
- additionis added
- temperaturethe reaction mixture is heated
- temperatureat reflux temperature for 20 hours
- filtrationthe precipitated crystalline material is filtered off
- customdried
출처 및 근거
- ORD 기록
- ord-849456b97daf4633bb5ea947dff32749
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- US08338411B2
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