HCID 59355026, 화합물 → 3-Amino-2-benzylpropanoic acid
반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][C:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)(CC(OCC)=O)[C:14]([O:16]CC)=[O:15]>Cl.CC(O)=O>[NH2:3][CH2:12][CH:13]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:14]([OH:16])=[O:15]참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
A solution of diethyl 2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-2-(phenylmethyl)butanedioate (13 g, 31.8 mmole) in conc. HCl (125 mL) and HOAc (30 mL) was sealed in a 1 L screwcap reaction vessel and the contents heated to 120° C. for 48 h. The reaction solution was concentrated under vacuum and the resulting solids washed with Et2O affording the title compound (quant.) as a white solid: LCMS (ES) m/z 181(M+H)+.
후처리
- concentrationThe reaction solution was concentrated under vacuum
- washthe resulting solids washed with Et2O affording the title compound (quant.) as a white solid
출처 및 근거
- ORD 기록
- ord-0b689ade446241bebcd7ca9b5a304545
- 출처 데이터셋
- uspto-grants-2012_12
- 특허 번호
- US08338434B2
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