Water → 2-(Benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine

HRID 2196449

반응식

HRID 2196449 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.C(=O)([O-])O.[Na+].O.[O:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([C:24](=O)[CH2:25]Br)=[CH:16]1>C(O)CC>[O:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[C:17]([C:24]2[N:8]=[C:5]3[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][N:6]3[CH:25]=2)=[CH:16]1

참가 물질

6

반응물 4

HCID 962WaterHCID 706222-Amino-5-bromopyridineHCID 516892Sodium BicarbonateHCID 27765801-(Benzofuran-3-yl)-2-bromoethanone

생성물 1

HCID 686400892-(Benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine수율 76.3%

시약·촉매·용매 1

HCID 10311-Propanol용매

반응 조건

온도
80 °C

실험 절차

In a glass tube, 250 mg of 1-(benzofuran-3-yl)-2-bromoethanone, 181 mg of 5-bromopyridin-2-ylamine and 105 mg of sodium hydrogencarbonate are dissolved in 15 ml of n-propanol. The tube is closed and heated at 80° C. for 20 h. After cooling, 20 ml of water are added and the reaction mixture is stirred for 1 hour at ambient temperature. A precipitate forms, and is recovered by filtration, washed with water and then with diisopropyl ether, and dried in a desiccator under reduced pressure. 250 mg of compound are obtained.

후처리

  1. customThe tube is closed
  2. temperatureAfter cooling
  3. filtrationA precipitate forms, and is recovered by filtration
  4. washwashed with water
  5. dry with materialwith diisopropyl ether, and dried in a desiccator under reduced pressure

출처 및 근거

ORD 기록
ord-d9ba4379f2634dfd9d2d565c0af60c07
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338451B2

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