참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Amino-5-bromopyridine | HCID 70622 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-(Benzofuran-3-yl)-2-bromoethanone | HCID 2776580 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | 2-(Benzofuran-3-yl)-6-bromoimidazo[1,2-a]pyridine | HCID 68640089 | 76.3% |
반응 단계
In a glass tube, 250 mg of 1-(benzofuran-3-yl)-2-bromoethanone, 181 mg of 5-bromopyridin-2-ylamine and 105 mg of sodium hydrogencarbonate are dissolved in 15 ml of n-propanol. The tube is closed and heated at 80° C. for 20 h. After cooling, 20 ml of water are added and the reaction mixture is stirred for 1 hour at ambient temperature. A precipitate forms, and is recovered by filtration, washed with water and then with diisopropyl ether, and dried in a desiccator under reduced pressure. 250 mg of compound are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08338451B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_12 |
|---|
| ORD ID | ord-d9ba4379f2634dfd9d2d565c0af60c07 |
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| 출처 메모 | uspto-grants-2012_12 |
|---|
