Hydrochloric Acid → [3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

HRID 2196455노트

반응식

HRID 2196455 반응식
[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1.[ClH:24]>ClCCl.CO.C(O)(C)C>[ClH:24].[CH3:1][C:2]1[N:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[C:13]([CH2:17][OH:18])[CH:14]=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[C:19]1[S:20][CH:21]=[CH:22][CH:23]=1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 44231018[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol

생성물 1

HCID 44231017[3-(3-Methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol hydrochloride

시약·촉매·용매 3

HCID 887Methanol용매HCID 3776Isopropanol용매HCID 6344Dichloromethane용매

실험 절차

140 mg of [3-(3-methyl-2-thien-2-ylimidazo[1,2-a]pyridin-6-yl)phenyl]methanol are suspended in dichloromethane and methanol; 3.2 ml of a 0.1N solution of hydrochloric acid in isopropanol are added thereto, dropwise. The reaction mixture is then concentrated under reduced pressure. The residual solid is taken up in diethyl ether, and the precipitate is recovered by filtration and oven-dried under reduced pressure. 150 mg of compound are obtained.

후처리

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. filtrationthe precipitate is recovered by filtration
  3. customoven-dried under reduced pressure

출처 및 근거

ORD 기록
ord-15135a70d3f345c7aa492b4069a6eab4
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338451B2

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