Sodium borohydride → (2-Bromo-6-fluorophenyl)methanol

HRID 2196457노트

반응식

HRID 2196457 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][OH:5]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 224739772-Bromo-6-fluorobenzaldehyde

생성물 1

HCID 44181801(2-Bromo-6-fluorophenyl)methanol수율 89.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

20.0 g (0098 mol) of 2-bromo-6-fluorobenzaldehyde are dissolved in 500 ml of methanol and cooled in an ice bath; 3.72 g (0.098 mol) of sodium borohydride are then added thereto, portionwise. The mixture is stirred under cold conditions for 1 hour and the solvent is then evaporated off under reduced pressure. The residue is taken up between water and dichloromethane, and the organic phase is separated, dried and concentrated under reduced pressure. The residue is crystallized from pentane. 18.1 g of compound are obtained.

후처리

  1. temperaturecooled in an ice bath
  2. customthe solvent is then evaporated off under reduced pressure
  3. customthe organic phase is separated
  4. customdried
  5. concentrationconcentrated under reduced pressure
  6. customThe residue is crystallized from pentane

출처 및 근거

ORD 기록
ord-3b776c9206ec4bdf9851abee129f4ea4
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338451B2

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