Hydrochloric Acid → HCID 69299496, 화합물

HRID 2196500노트

반응식

HRID 2196500 반응식
[C:1]([C:3]1[S:7][CH:6]=[C:5]([N:8](C(OC(C)(C)C)=O)[NH:9]C(OC(C)(C)C)=O)[CH:4]=1)#[N:2].[ClH:24].O1CCOCC1>CC(O)C>[ClH:24].[NH:8]([C:5]1[CH:4]=[C:3]([C:1]#[N:2])[S:7][CH:6]=1)[NH2:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59843278Di-tert-butyl 1-(5-cyanothiophen-3-yl)hydrazine-1,2-dicarboxylate

생성물 1

HCID 69299496HCID 69299496, 화합물수율 97%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a stirring solution of compound 12 (1.38 g, 4.07 mmol) in 2-propanol (10 mL) was added 4M HCl in dioxane (10 mL, 40.0 mmol). The reaction heated to 80 degrees for 1 hour turning into a dark brown solution. The mixture was evaporated to dryness and the resulting the brown solid suspended and sonicated in diethyl ether. The suspension was filtered to afford compound 13 (0.701 g, 97%) as a brown solid. LRMS (ESI): calc. 139.0; found 140.1 (MH)+.

후처리

  1. temperatureThe reaction heated to 80 degrees for 1 hour
  2. customThe mixture was evaporated to dryness
  3. customsonicated in diethyl ether
  4. filtrationThe suspension was filtered

출처 및 근거

ORD 기록
ord-7e624a66ce7e4c598f259738cf1ddbb4
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338437B2

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