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Diisopropylethylamine → 2-(3,5-Difluorophenyl)-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide

HRID 219653
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HRID 219653 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[CH:13][C:12]([C:15]([OH:17])=O)=[CH:11][N:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.C(N(C(C)C)CC)(C)C.[CH3:27][NH:28][S:29]([C:32]1[CH:33]=[C:34]([CH:37]=[CH:38][CH:39]=1)[CH2:35][NH2:36])(=[O:31])=[O:30]>CN(C=O)C>[CH3:27][NH:28][S:29]([C:32]1[CH:33]=[C:34]([CH:37]=[CH:38][CH:39]=1)[CH2:35][NH:36][C:15]([C:12]1[CH:13]=[N:14][C:9]([C:4]2[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=2)=[N:10][CH:11]=1)=[O:17])(=[O:30])=[O:31]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 167855973-(aminomethyl)-N-methylbenzenesulfonamideHCID 450733652-(3,5-Difluorophenyl)pyrimidine-5-carboxylic acid

생성물 1

HCID 598058332-(3,5-Difluorophenyl)-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide수율 62%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매
2회

실험 절차

A mixture of 2-(3,5-difluoro-phenyl)-pyrimidine-5-carboxylic acid (118 mg, 0.5 mmol, prepared according to the general procedure described in Example 2, steps 1 and 2) and O-(7-azabenzotriazol-1-yl)-N,N,N,N-tetramethyluronium hexafluorophosphate (190 mg, 0.5 mmol) in dry DMF (5 mL) is treated with diisopropylethylamine (0.09 mL) and stirred at room temperature for 30 min. A solution of 3-methylsulfamoylbenzylamine (150 mg, 0.75 mmol.) in dry DMF (1 mL) is added and the mixture stirred at room temperature for 24 hours. The solvent is removed and the residue is partitioned between EtOAc and water. The organic phase is separated and washed with saturated NaHCO3, water and brine, dried (MgSO4), filtered and concentrated in vacuo. The residue is purified by column chromatography eluting with 30% EtOAc in DCM to afford 2-(3,5-difluorophenyl)-pyrimidine-5-carboxylic acid 3-methylsulfamoyl-benzylamide (125 mg, 62%) as a solid. MS: 419 (M+H); 1H NMR (300 MHz, DMSO-d6): δ 2.41 (d, 3H), 4.64 (d, 2H), 7.43-7.75 (m, 5H), 7.80 (s, 1H), 8.05 (d, 2H), 9.37 (s, 2H), 9.60 (t, 1H); IC50=49 nM.

후처리

  1. customprepared
  2. stirringthe mixture stirred at room temperature for 24 hours
  3. customThe solvent is removed
  4. customthe residue is partitioned between EtOAc and water
  5. customThe organic phase is separated
  6. washwashed with saturated NaHCO3, water and brine
  7. dry with materialdried (MgSO4)
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo
  10. customThe residue is purified by column chromatography
  11. washeluting with 30% EtOAc in DCM

출처 및 근거

ORD 기록
ord-99bdff64019446a6a0355e43b2f4e016
출처 데이터셋
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08202863B2

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