Water → HCID 69300599, 화합물

HRID 2196531노트

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HRID 2196531 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]([C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[C:14]#[N:15])[N:9]=[C:8]([C:19]([F:22])([F:21])[F:20])[CH:7]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C1COCC1>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:10]([C:11]2[CH:12]=[C:13]([CH2:14][NH2:15])[CH:16]=[CH:17][CH:18]=2)[N:9]=[C:8]([C:19]([F:21])([F:20])[F:22])[CH:7]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 158809863-[3-(Trifluoromethyl)-5-(2-furanyl)-1H-pyrazole-1-yl]benzonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 69300599HCID 69300599, 화합물수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 53 (3 g, 9.89 mmol) in THF (50 mL) at 0° C. was added lithium aluminium hydride (0.939 g, 24.73 mmol). The resulting suspension was allowed to stir for 0.5 h. The reaction mixture was then warmed to room temperature and stirred for another 1 h. The following was added sequentially: 0.9 mL of water, 0.9 mL of 15% NaOH and 1.8 mL of water. The white solid was removed by filtration and the filtrate evaporated under vacuum. The title product 54 (3.04 g, 100% yield) was isolated as a pale yellow oil. Crude was used without any further purification. LRMS (ESI): calc. 307.3; found 308.4 (MH)+.

후처리

  1. stirringstirred for another 1 h
  2. additionThe following was added sequentially
  3. customThe white solid was removed by filtration
  4. customthe filtrate evaporated under vacuum

출처 및 근거

ORD 기록
ord-7c3ac86c7c5f4d36a3db2df3297dfda9
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338437B2

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