2-[4-(4-Bromophenoxymethyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyric acid methyl ester → HCID 66660886, 화합물

HRID 2197271노트

반응식

HRID 2197271 반응식
C[O:2][C:3](=[O:29])[CH:4]([NH:8][C:9](=[O:28])[CH:10]([NH:20][C:21](OC(C)(C)C)=[O:22])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][CH:14]=1)[CH:5]([CH3:7])[CH3:6].COC(=O)C(N1C(=O)C(COC2C=CC(Br)=CC=2)NC1=O)C(C)C>Cl>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][CH2:11][CH:10]2[C:9](=[O:28])[N:8]([CH:4]([CH:5]([CH3:7])[CH3:6])[C:3]([OH:2])=[O:29])[C:21](=[O:22])[NH:20]2)=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 666606712-[4-(4-Bromophenoxymethyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyric acid methyl esterHCID 666609032-[3-(4-Bromophenoxy)-2-tert-butoxycarbonylamino-propionylamino]-3-methyl-butyric acid methyl ester

생성물 1

HCID 66660886HCID 66660886, 화합물수율 41%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
80 °C

실험 절차

A mixture of the compound obtained in step g above (22g) (759 mg, 1.907 mmol) and 3 N HCl (20 mL) was stirred at 80° C. for 2 h. The reaction mixture was cooled down and then extracted with EtOAc. The combined organic layers were dried and concentrated; the crude product was purified by silica gel column chromatography which gave the title compound as colorless oil (300 mg, 41%).

후처리

  1. temperatureThe reaction mixture was cooled down
  2. extractionextracted with EtOAc
  3. customThe combined organic layers were dried
  4. concentrationconcentrated
  5. customthe crude product was purified by silica gel column chromatography which

출처 및 근거

ORD 기록
ord-98db85b568764f85b90ed13c5b86b72e
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338471B2

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