Diphenyl Ether → Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate

HRID 2197690

반응식

HRID 2197690 반응식
C1(OC2C=CC=CC=2)C=CC=CC=1.C(O[C:17](=[O:33])[C:18](=[CH:24][NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[N:27]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])C>CCCCCC>[CH2:22]([O:21][C:19]([C:18]1[C:17](=[O:33])[C:31]2[C:26](=[N:27][C:28]([CH3:32])=[CH:29][CH:30]=2)[NH:25][CH:24]=1)=[O:20])[CH3:23]

참가 물질

4

반응물 2

HCID 7583Diphenyl EtherHCID 83264Diethyl [[(6-methyl-2-pyridyl)amino]methylene]malonate

생성물 1

HCID 5373687Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate수율 71%

시약·촉매·용매 1

HCID 8058Hexane용매

반응 조건

온도
250 °C

실험 절차

A solution of diphenyl ether was heated to 250° C. and the product of Example 1a (2.50 g, 9.0 mmol) was added in several small portions over a period of about 5 min then heated at 250° C. for 30 min. After cooling to room temperature diluted with hexane. The resulting solid was filtered and was dried under vacuum giving the title compound as a tan solid (1.47 g, 71%).

후처리

  1. temperatureAfter cooling to room temperature
  2. filtrationThe resulting solid was filtered
  3. customwas dried under vacuum

출처 및 근거

ORD 기록
ord-a1d2c090bb7344c68a13d0d54f93a80e
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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