Iodoethane → 2-(2,5-Dimethyl-pyrrol-1-yl)-6-propyl-pyridine

HRID 2197696노트

반응식

HRID 2197696 반응식
[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[Li+].[CH3:16][CH:17]([N-]C(C)C)C.C(I)C>C1COCC1>[CH3:7][C:4]1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][CH2:16][CH3:17])[N:9]=2)[C:2]([CH3:1])=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 7931562-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-methylpyridineHCID 2724682Lithium diisopropylamide

생성물 1

HCID 542277792-(2,5-Dimethyl-pyrrol-1-yl)-6-propyl-pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

반응 조건

온도
-30 °C

실험 절차

A solution of the product from Example 2a (7.53 g, 40.0 mmol) in 30 mL of dry THF was added dropwise with stirring to a solution of LDA (42.4 mmol) in 30 mL of dry THF at −30° C. Stirred at −30° C. for 30 min. Added EtI (3.42 mL, 42.0 mmol) in 20 mL of dry THF dropwise with stirring for 30 min then warmed to room temperature. After 2 h quenched by pouring into saturated NaCl solution and extracted with ether. Dried over MgSO4, filtered and concentrated under vacuum giving the title compound. The product was purified by silica gel column chromatography eluting with EtOAc/hexane to give the title compound (5.21 g, 60%).

후처리

  1. temperaturethen warmed to room temperature
  2. customAfter 2 h quenched
  3. additionby pouring into saturated NaCl solution
  4. extractionextracted with ether
  5. dry with materialDried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-54ccb51e2ba74ae58ac3698404a40e06
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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