Phosphorus oxychloride → 4-Chloro-2,7-dimethyl-[1,8]naphthyridine

HRID 2197728노트

반응식

HRID 2197728 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10](=O)[CH:11]=1)=[CH:8][CH:7]=[C:6]([CH3:13])[N:5]=2.O=P(Cl)(Cl)[Cl:16]>>[Cl:16][C:10]1[C:9]2[C:4](=[N:5][C:6]([CH3:13])=[CH:7][CH:8]=2)[N:3]=[C:2]([CH3:1])[CH:11]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 106788172,7-Dimethyl-1,8-naphthyridin-4-ol

생성물 1

HCID 112063334-Chloro-2,7-dimethyl-[1,8]naphthyridine

실험 절차

The product from Example 14a (500 mg, 2.87 mmol) was reacted with 10 mL of POCl3 for 2 h following the procedure from Example 1d giving the title compound, which was used without purification.

출처 및 근거

ORD 기록
ord-ca6ad19598ed4af28024d25a7c8df126
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08338605B2

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