10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane → 10-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid

HRID 21981

반응식

HRID 21981 반응식
[SH:1][CH2:2][CH:3]1[NH:12][C:11](=[O:13])[CH:10]([CH2:14][C:15]([O:17]C(C)(C)C)=[O:16])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[NH:12][C:11](=[O:13])[CH:10]([CH2:14][C:15]([OH:17])=[O:16])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

참가 물질

3

반응물 1

HCID 1993080710-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane

생성물 1

HCID 1993085410-Mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

10-Mercaptomethyl-3-t-butoxycarbonylmethyl-2-oxo-1-azacyclodecane (0.21 g, 0.69 mmol) is dissolved in methylene chloride (15 mL). Gaseous hydrogen chloride is bubbled through the solvent for 15 minutes, and then the reaction is sealed and stirred overnight. The solvent is evaporated the next day to give 10-mercaptomethyl-2-oxo-1-azacyclodecane-3-acetic acid, MS: M+1=260.

후처리

  1. customGaseous hydrogen chloride is bubbled through the solvent for 15 minutes
  2. customthe reaction is sealed
  3. customThe solvent is evaporated the next day

출처 및 근거

ORD 기록
ord-46950eaab8e34cc2a47f6fa0233b2643
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05426103

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