4-Aminobenzoic Acid → 4-(8-Trifluoromethyl-4-quinolylamino)benzoic acid

HRID 2198486

반응식

HRID 2198486 반응식
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=1>Cl.O>[F:13][C:12]([F:15])([F:14])[C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[CH:4][CH:3]=[C:2]2[NH:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=1

참가 물질

5

반응물 2

HCID 9784-Aminobenzoic AcidHCID 902624-Chloro-8-(trifluoromethyl)quinoline

생성물 1

HCID 205201244-(8-Trifluoromethyl-4-quinolylamino)benzoic acid수율 96.6%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매2회

반응 조건

온도
90 °C

실험 절차

23.16 Grams (0.1 mole) of 4-chloro-8-trifluoromethyl quinoline were dissolved in 22 milliliters of concentrated hydrochloric acid and 150 milliliters of water and the solution was added in a stream to a vigorously stirred solution of 13.7 grams (0.1 mole) of p-aminobenzoic acid in 150 milliliters of water at 60° C. The mixture was heated at 90° C. for 2 hours, cooled, and the solid collected and recrystallized from ethanol to give 32.1 grams (83%) of the title compound as the hydrochloride monohydrate, melting point 262°-265° C.(d).

후처리

  1. temperaturecooled
  2. customthe solid collected
  3. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-5918e2de27dd4cb7ac54e02e54c3aa30
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04357333

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