Hydrochloric Acid → HCID 20477659, 화합물

HRID 2198511노트

반응식

HRID 2198511 반응식
C([O:3][C:4]([CH:6]1[C:8]([CH3:10])([CH3:9])[CH:7]1[C:11]#[N:12])=[O:5])C.[OH-].[K+].Cl>O.C(O)C>[C:11]([CH:7]1[C:8]([CH3:10])([CH3:9])[CH:6]1[C:4]([OH:5])=[O:3])#[N:12]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 128503382,2-Dimethyl-3-ethoxycarbonyl-cyclopropane-1-carbonitrile

생성물 1

HCID 20477659HCID 20477659, 화합물수율 76.2%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A suspension of 33.4 g (0.2 mol) of 2-cyano-3,3-dimethyl-cyclopropane-carboxylic acid ethyl ester and 16.8 g (0.3 mol) of potassium hydroxide in 200 ml of water and 100 ml of ethanol was stirred at 20°-25° C. for 15 hours. The alcohol was then stripped off and the aqueous solution was acidified with dilute hydrochloric acid and extracted twice with 100 ml of ether (or methylene chloride) each time. The combined organic extracts were dried over Na2SO4 and concentrated and the residue was distilled. 21.2 g (76% of theory) of 2-cyano-3,3-dimethyl-cyclopropane-carboxylic acid were obtained in the form of an oil of boiling point 110°-120° C., which crystallized on cooling (melting point: 101°-106° C.). ##STR44##

후처리

  1. extractionextracted twice with 100 ml of ether (or methylene chloride) each time
  2. dry with materialThe combined organic extracts were dried over Na2SO4
  3. concentrationconcentrated
  4. distillationthe residue was distilled

출처 및 근거

ORD 기록
ord-dc88db577a54489bbbf7a08b2a456936
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04358409

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