Potassium cyanate → (9,10-Dihydro-9,10-methano-9-anthryl)acetonitrile

HRID 2198650

반응식

HRID 2198650 반응식
S(O[CH2:12][C:13]12[CH2:27][CH:20]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=31)[C:19]1[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=1)(C1C=CC(C)=CC=1)(=O)=O.[O-][C:29]#[N:30].[K+]>CN(C)C=O.O>[CH:15]1[C:14]2[C:13]3([CH2:12][C:29]#[N:30])[CH2:27][CH:20]([C:21]4[C:26]3=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:19]=2[CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 2

HCID 11378442Potassium cyanateHCID 205199599-Tosyloxymethyl-9,10-dihydro-9,10-methanoanthracene

생성물 1

HCID 13069087(9,10-Dihydro-9,10-methano-9-anthryl)acetonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
150 °C

실험 절차

A mixture of 9-tosyloxymethyl-9,10-dihydro-9,10-methanoanthracene (188 mg) and potassium cyanate (40 mg) in dimethylformamide (2 ml) was heated at 150° C. for 7 hours. The reaction mixture was diluted with water and extracted with benzene. The benzene extract was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness to give crude crystals of (9,10-dihydro-9,10-methano-9-anthryl)acetonitrile, which was recrystallized from isopropanol to give pure crystals. M.P. 130°-131° C.

후처리

  1. extractionextracted with benzene
  2. extractionThe benzene extract
  3. washwas washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-94d72a7e56384f7589e3e478ca5d4832
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04358620

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