Methanol → HCID 12249281, 화합물

HRID 2198818노트

반응식

HRID 2198818 반응식
[O:1]=[C:2]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:14][C:15]([OH:17])=[O:16].S(=O)(=O)(O)O.[OH-].[Na+].[CH3:25]O>[O-]S([O-])(=O)=O.[Na+].[Na+]>[CH3:25][O:16][C:15](=[O:17])[CH2:14][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:2]1=[O:1]

참가 물질

6

반응물 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 317519Cyclododecaneaceticacid, 2-oxo-

생성물 1

HCID 12249281HCID 12249281, 화합물수율 97%

시약·촉매·용매 1

HCID 24436Sodium Sulfate촉매

실험 절차

One hundred seventy-five grams (0.73 mol) of the ketomono acid from step 3 and 440 ml of methanol were refluxed with agitation for 3 hours with the addition of 7.3 gm of concentrated sulfuric acid. The cooled solution was neutralized with 50% sodium hydroxide solution and then methanol and water were completely removed. The residue contained, in addition to small amounts of salt (approximately 10 gm of Na2SO4), approximately 180 gm of ketomonoester (IX) (97% yield), which was further reacted in that form.

후처리

  1. custommethanol and water were completely removed

출처 및 근거

ORD 기록
ord-f87eedfd9ec7431e8d515adf77301e2b
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04360468

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