Isopropylamine → 1-(Iso-propyl)-3-benzyloxyazetidine

HRID 2198856

반응식

HRID 2198856 반응식
[CH2:1]([O:8][CH:9]([CH2:12]Br)[CH2:10]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:14]([NH2:17])([CH3:16])[CH3:15]>O>[CH2:1]([O:8][CH:9]1[CH2:12][N:17]([CH:14]([CH3:16])[CH3:15])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 561824(((1,3-Dibromopropan-2-yl)oxy)methyl)benzene

생성물 1

HCID 205173241-(Iso-propyl)-3-benzyloxyazetidine

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

11 Parts of 2-benzyloxy-1,3-dibromo-propane, 30 parts of iso-propylamine and 30 parts of water were added to a stainless autoclave, and the mixture was heated at 80° C. for 2 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 29, followed by distillation under reduced pressure. As a result, 18 parts of 3-benzyloxy-1-(iso-propyl)azetidine boiling at 104°-107° C. under 2 mm Hg were obtained.

후처리

  1. temperatureThe reaction mixture was cooled
  2. additiontreated in the same manner as in Example 29
  3. distillationfollowed by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-254474e6da6d4692a5dc96eee36f2060
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04360464

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