HCID 2799775, 화합물 → Imidazo[1,5-a]pyridine-3-acetonitrile

HRID 2199048노트

반응식

HRID 2199048 반응식
[C:1]([CH2:3][C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=O)#[N:2]>P(Cl)(Cl)(Cl)=O>[C:1]([CH2:3][C:4]1[N:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]2=[CH:7][N:6]=1)#[N:2]

참가 물질

3

반응물 1

HCID 2799775HCID 2799775, 화합물

생성물 1

HCID 21265783Imidazo[1,5-a]pyridine-3-acetonitrile

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

Heat under reflux for 0.5 hours a mixture of 9 gm (0.06 mol) 2-cyano-N-(2-pyridylmethyl)acetamide and 100 ml phosphorous oxychloride. Cool the reaction mixture to room temperature and remove the phosphorus oxychloride under reduced pressure. Partition the residue between chloroform and a solution of sodium bicarbonate. Separate the chloroform layer and dry over anhydrous potassium carbonate. Filter and remove the chloroform under reduced pressure. Chromatograph the resulting residue on silica gel using ethyl acetate-chloroform to give the desired product, 3-cyanomethyl imidazo[1,5-a]pyridine, as determined by IR, NMR and elemental analysis, m.p. 64°-66°.

후처리

  1. temperatureHeat
  2. temperatureunder reflux for 0.5 hours
  3. customremove the phosphorus oxychloride under reduced pressure
  4. customPartition the residue between chloroform
  5. customSeparate the chloroform layer
  6. dry with materialdry over anhydrous potassium carbonate
  7. filtrationFilter
  8. customremove the chloroform under reduced pressure

출처 및 근거

ORD 기록
ord-416af44747254a58ba5d0a71748e93d0
출처 데이터셋
uspto-grants-1982_11
특허 번호
US04361567

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