Hydrazine hydrate (1:1) → N-tert-butyl-6-hydrazino-N-methylpyridine-3-sulfonamide

HRID 2199592노트

반응식

HRID 2199592 반응식
[C:1]([N:5]([CH3:16])[S:6]([C:9]1[CH:10]=[N:11][C:12](Cl)=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:18][NH2:19]>>[C:1]([N:5]([CH3:16])[S:6]([C:9]1[CH:10]=[N:11][C:12]([NH:18][NH2:19])=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 86659955N-tert-butyl-6-chloro-N-methylpyridine-3-sulfonamide

생성물 1

HCID 67456669N-tert-butyl-6-hydrazino-N-methylpyridine-3-sulfonamide수율 84%

실험 절차

According to the process described in Example 4.2, starting with 0.66 g (2.53 mmol) of N-tert-butyl-6-chloro-N-methylpyridine-3-sulfonamide and 0.46 mL of hydrazine monohydrate, 0.55 g of N-tert-butyl-6-hydrazino-N-methylpyridine-3-sulfonamide is obtained in the form of a white solid, which is used without further purification in the following step.

출처 및 근거

ORD 기록
ord-645818e56d0847ff9d74bc050202aee8
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359329B2

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