N-Iodosuccinimide → HCID 68939125, 화합물

HRID 2199757노트

반응식

HRID 2199757 반응식
[C:1]1([CH3:21])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:15]=1[NH:14][C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:12]2.[I:22]N1C(=O)CCC1=O>ClCCl>[I:22][C:12]1[C:11]2[C:15](=[C:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=3[CH3:21])[CH:8]=[CH:9][CH:10]=2)[NH:14][C:13]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

참가 물질

4

반응물 2

HCID 120273N-IodosuccinimideHCID 68940392HCID 68940392, 화합물

생성물 1

HCID 68939125HCID 68939125, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of EXAMPLE 564A (944 mg, 3.38 mmol) in dichloromethane (10 mL) was added 1-iodopyrrolidine-2,5-dione (798 mg, 3.55 9 mmol). The reaction mixture was stirred at room temperature for 3 hours and directly loaded on a flash column, eluting with hexane first and then with 0-50% hexane in dichloromethane. The title compound was obtained as a white solid.

후처리

  1. washeluting with hexane first

출처 및 근거

ORD 기록
ord-46f540eb484e47548d3ef0d2f3f9a5d5
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359296B2

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