Water → (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)propanamide
반응식
[Cl:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][CH:5]=[C:6](Cl)[N:7]=1.Cl.[NH2:12][C@@H:13]([C:15]([NH2:17])=[O:16])[CH3:14].CCN(C(C)C)C(C)C.O>CN1C(=O)CCC1.CCOC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([NH:12][C@H:13]([CH3:14])[C:15]([NH2:17])=[O:16])[CH:5]=[N:4][C:3]=1[C:9]#[N:10]참가 물질
7
실험 절차
A solution of 3,5-dichloropyrazine-2-carbonitrile (150 mg, 0.862 mmol), D-alaninamide hydrochloride (107 mg, 0.858 mmol) and DIEA (0.400 mL, 2.30 mmol) in NMP (4 mL) was stirred at room temperature for 20 h. Water and EtOAc were added. Organic phase was separated, dried over Na2SO4, concentrated in vacuo to give (R)-2-(6-chloro-5-cyanopyrazin-2-ylamino)propanamide as an oil (194 mg).
후처리
- customOrganic phase was separated
- dry with materialdried over Na2SO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-1074a1a6f609496989432d1b8c87a0b6
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09359308B2
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