Sodium borohydride → 3-(6-(4-(4-Chlorothiazol-2-yl)-4-hydroxybutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

HRID 2201214노트

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HRID 2201214 반응식
[BH4-].[Na+].[Cl:3][C:4]1[N:5]=[C:6]([C:9](=[O:34])[CH2:10][CH2:11][CH2:12][N:13]2[C:21]([C:22]3[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=3)[C:25]#[N:26])=[C:20]3[C:15]([N:16]([CH3:33])[C:17](=[O:32])[N:18]([CH3:31])[C:19]3=[O:30])=[CH:14]2)[S:7][CH:8]=1>C(O)C>[Cl:3][C:4]1[N:5]=[C:6]([CH:9]([OH:34])[CH2:10][CH2:11][CH2:12][N:13]2[C:21]([C:22]3[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=3)[C:25]#[N:26])=[C:20]3[C:15]([N:16]([CH3:33])[C:17](=[O:32])[N:18]([CH3:31])[C:19]3=[O:30])=[CH:14]2)[S:7][CH:8]=1

참가 물질

4

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HCID 4311764Sodium borohydrideHCID 867234533-(6-(4-(4-Chlorothiazol-2-yl)-4-oxobutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

생성물 1

HCID 867234543-(6-(4-(4-Chlorothiazol-2-yl)-4-hydroxybutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
0 °C

실험 절차

Sodium borohydride (0.606 g, 16.03 mmol) was added portionwise to a suspension of 3-(6-(4-(4-chlorothiazol-2-yl)-4-oxobutyl)-1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile (2.5 g, 5.34 mmol) in ethanol (53.4 mL) at 0° C. The reaction mixture was stirred for 15 minutes at 0° C., the quenched with water (25 mL) and extracted with DCM (3×50 mL). The combined organic fractions were dried over magnesium sulfate and evaporated under reduced pressure to afford the title compound.

후처리

  1. customthe quenched with water (25 mL)
  2. extractionextracted with DCM (3×50 mL)
  3. dry with materialThe combined organic fractions were dried over magnesium sulfate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-cb5f337bcaa4468798ba3b00614be78d
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359381B2

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