Dichloromethane → (1-Chloro-3-((4-methoxybenzyl)oxy)propan-2-yl)(trityl)sulfane

HRID 2201224노트

반응식

HRID 2201224 반응식
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][O:8][CH2:9][CH:10]2[CH2:12][S:11]2)=[CH:5][CH:4]=1.[C:15](Cl)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Cl:35]CCl>>[Cl:35][CH2:12][CH:10]([S:11][C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:9][O:8][CH2:7][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:14][CH:13]=1

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 6456Trityl chlorideHCID 867234592-(((4-Methoxybenzyl)oxy)methyl)thiirane

생성물 1

HCID 86723460(1-Chloro-3-((4-methoxybenzyl)oxy)propan-2-yl)(trityl)sulfane

실험 절차

2-(((4-Methoxybenzyl)oxy)methyl)thiirane (496 mg, 2.359 mmol) was added to a solution of trityl chloride (598 mg, 2.144 mmol) in dichloromethane (10 mL). The mixture was stirred at room temperature for 16 hours, then evaporated under vacuum. Purification by chromatography on silica, eluting with 0-5% EtOAc/hexane, gave a crude material which was triturated with methanol to afford the title compound.

후처리

  1. customevaporated under vacuum
  2. customPurification by chromatography on silica
  3. washeluting with 0-5% EtOAc/hexane
  4. customgave a crude material which
  5. customwas triturated with methanol

출처 및 근거

ORD 기록
ord-3134e65ea8b04e1faec6a6ae2f61234e
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359381B2

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