N-(2,3-Epoxypropyl)phthalimide → AGN-PC-0KLTOI

HRID 2201228노트

반응식

HRID 2201228 반응식
NC(N)=[S:3].O1[CH2:19][CH:6]1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:10]2[C:9]1=[O:18]>CO>[S:3]1[CH2:19][CH:6]1[CH2:7][N:8]1[C:12](=[O:13])[C:11]2[C:10](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]1=[O:18]

참가 물질

4

반응물 2

HCID 21601N-(2,3-Epoxypropyl)phthalimideHCID 2723790Thiourea

생성물 1

HCID 2828744AGN-PC-0KLTOI

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Thiourea (1.873 g, 24.61 mmol) was added to a solution of N-(2,3-epoxypropyl)phthalimide (2 g, 9.84 mmol) in methanol (25 mL). The mixture was stirred at room temperature for 16 hours, then concentrated under vacuum. The residue was diluted with water (50 ml) and extracted with ethyl acetate (50 ml). The organic extract was washed with brine (50 ml) passed through a hydrophobic frit and evaporated under vacuum. Purification by chromatography on silica, eluting with 0-50% EtOAc/hexane, afforded the title compound.

후처리

  1. concentrationconcentrated under vacuum
  2. additionThe residue was diluted with water (50 ml)
  3. extractionextracted with ethyl acetate (50 ml)
  4. extractionThe organic extract
  5. washwas washed with brine (50 ml)
  6. customevaporated under vacuum
  7. customPurification by chromatography on silica
  8. washeluting with 0-50% EtOAc/hexane

출처 및 근거

ORD 기록
ord-153f62342903406099735512a6d2db4a
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09359381B2

반응 노트

불러오는 중…