Acetic Anhydride → 1-(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one

HRID 2201322노트

반응식

HRID 2201322 반응식
[CH3:1][CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:12]([N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:10][CH2:11][CH:2]1[CH3:1])(=[O:14])[CH3:13]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 962892-Methyl-1,2,3,4-tetrahydroquinoline

생성물 1

HCID 2512901-(2-Methyl-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one수율 243.5%

실험 절차

2-Methyl-1,2,3,4-tetrahydroquinoline (216 mg, 1.469 mmol, available from TCl), was measured into a reaction test tube and acetic anhydride (0.139 ml, 1.469 mmol) was added and left to stir overnight. LCMS analysis showed the reaction had gone to completion. The crude product was purified by MDAP to give the desired compound (677 mg)

후처리

  1. waitleft
  2. customThe crude product was purified by MDAP

출처 및 근거

ORD 기록
ord-5279b24a60454a3eaa9af60440109343
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09360482B2

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