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Lithium hydroxide, monohydrate → (S)-13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oic acid

HRID 2201718
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HRID 2201718 반응식
[CH2:1]([C@@H:5]([C:22](=[O:29])[NH:23][CH2:24][C:25]([O:27]C)=[O:26])[NH:6][C:7](=[O:21])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:2]([CH3:4])[CH3:3].O[Li].O>C1COCC1.O>[CH2:1]([C@@H:5]([C:22](=[O:29])[NH:23][CH2:24][C:25]([OH:27])=[O:26])[NH:6][C:7](=[O:21])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:2]([CH3:4])[CH3:3]
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참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 86712539(S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oate

생성물 1

HCID 86712540(S)-13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oic acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (S)-methyl 13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oate (6w) in THF was added a solution of LiOH.H2O in water at room temperature. After 3 h, the reaction mixture was concentrated, diluted with water and acidified with a 1N aqueous solution of HCl to about pH 4-5. The mixture was stirred for 15 min and the white precipitate formed was filtered off, rinsed with water, and dried to afford (S)-13-isobutyl-2,2-dimethyl-4,11,14-trioxo-3-oxa-5,12,15-triazaheptadecan-17-oic acid (7w).

후처리

  1. concentrationthe reaction mixture was concentrated
  2. additiondiluted with water
  3. customthe white precipitate formed
  4. filtrationwas filtered off
  5. washrinsed with water
  6. customdried

출처 및 근거

ORD 기록
ord-ac67f9e9dd304a16a5875a1d9795987d
출처 데이터셋
uspto-grants-2016_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09365498B2

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