Lithium hydroxide, monohydrate → Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

HRID 220206노트

반응식

HRID 220206 반응식
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][N:8]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])(=[O:14])=[O:13])[CH2:7]1)=[O:5])C.O[Li:23].O>C1COCC1.CO.O>[Cl:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([N:8]1[CH2:9][CH2:10][CH2:11][CH:6]([C:4]([O-:5])=[O:3])[CH2:7]1)(=[O:13])=[O:14].[Li+:23]

참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 38620101-(2-Chloro-benzenesulfonyl)-piperidine-3-carboxylic acid ethyl ester

생성물 1

HCID 67131265Lithium 1-(2-chloro-benzenesulfonyl)-piperidine-3-carboxylate

시약·촉매·용매 1

HCID 21892291Methanol tetrahydrofuran water용매

실험 절차

To a solution of 5.7 g 1-(2-chloro-benzenesulfonyl)-piperdine-3-carboxylic acid ethyl ester (17 mmol) in 30 mL THF: methanol: water (2:1:1) was added 1.08 g LiOH.H2O (25.7 mmol). The mixture was stirred at room temperature for 5-6 h and all volatiles were evaporated to dryness. The compound was used in the consecutive step without further purification.

후처리

  1. customall volatiles were evaporated to dryness
  2. customThe compound was used in the consecutive step without further purification

출처 및 근거

ORD 기록
ord-451a63a2c58144919bdae4ecfb673cf6
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202888B2

반응 노트

불러오는 중…