Hydrochloric Acid → 4-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

HRID 2202151노트

반응식

HRID 2202151 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Cl>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[NH:10][N:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 7075709HCID 7075709, 화합물

생성물 1

HCID 4491264-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]piperidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

INTERMEDIATE 7 was obtained by removal of the Boc group of INTERMEDIATE 1 with an acid. To a solution of INTERMEDIATE 1 (2.5 g, 6.92 mmol) in dichloromethane (10 mL) was added 4 M HCl (10 mL, 40 mmol in dioxane). The mixture was stirred at room temperature overnight. Solvent was evaporated under reduced pressure, and the residue was dried under vacuum.

후처리

  1. customSolvent was evaporated under reduced pressure
  2. customthe residue was dried under vacuum

출처 및 근거

ORD 기록
ord-cda3817722e7482f9746793aec41522b
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365539B2

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