Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pentanenitrile, 4,4-dimethyl-3-oxo- → 4-(5-Amino-3-tert-butyl-1H-pyrazol-1-yl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| 반응물 | 4-Cyanophenylhydrazine Hydrochloride | HCID 16212962 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(5-Amino-3-tert-butyl-1H-pyrazol-1-yl)benzonitrile | HCID 7147083 | 82.1% |
반응 단계
A flask was charged with 4-hydrazinylbenzonitrile hydrochloride (0.70 g, 3.8 mmol.), 4,4-dimethyl-3-oxopentanenitrile (0.48 g, 3.8 mmol) and MeOH and the reaction was heated at refluxed overnight. The reaction was cooled, and the solids which formed upon cooling were filtered off and discarded. Additional solids formed upon further standing (product) along with product material in solution. The solution containing, the solids was concentrated to yield 0.75 g of solid product (92%). MS M+1 (241).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08202899B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-47f23733431e4f64928cf6f1025ffbcb |
| 출처 메모 | uspto-grants-2012_06 |