Sodium Hydroxide → 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-ethoxy-5-(trifluoromethyl)picolinic acid

HRID 2202519노트

반응식

HRID 2202519 반응식
[CH3:1][C:2]1[N:3]([C:8]2[C:9]([C:21]([O:23]C)=[O:22])=[N:10][C:11]([O:18][CH2:19][CH3:20])=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[OH-].[Na+]>C1COCC1>[CH3:7][C:4]1[N:3]([C:8]2[C:9]([C:21]([OH:23])=[O:22])=[N:10][C:11]([O:18][CH2:19][CH3:20])=[C:12]([C:14]([F:15])([F:16])[F:17])[CH:13]=2)[C:2]([CH3:1])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67383877Methyl 3-(2,5-dimethyl-1H-pyrrol-1-yl)-6-ethoxy-5-(trifluoromethyl)picolinate

생성물 1

HCID 584423293-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-ethoxy-5-(trifluoromethyl)picolinic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methyl 3-(2,5-dimethyl-1H-pyrrol-1-yl)-6-ethoxy-5-(trifluoromethyl)picolinate (140 mg, 0.409 mmol) was dissolved in THF (2.045 ml). NaOH (0.613 ml, 1.226 mmol) was added and heated at reflux for 6 hours. The solvent was removed in vacuo and the resulting mixture was diluted with EtOAc (25 ml) was acidified to pH 1 using HCl (5M). The organic portion washed with brine, dried using a phase separator and concentrated in vacuo to afford the title compound as a yellow oil.

후처리

  1. temperatureheated
  2. temperatureat reflux for 6 hours
  3. customThe solvent was removed in vacuo
  4. additionthe resulting mixture was diluted with EtOAc (25 ml)
  5. washThe organic portion washed with brine
  6. customdried
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-130746b1b8bc4cbfb79c666b1db7a536
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365552B2

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