Trifluoroacetic acid → HCID 178483309, 화합물

HRID 220252

반응식

HRID 220252 반응식
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C:11]1[NH:15][C:14]2[C:16]([O:20][CH3:21])=[CH:17][CH:18]=[CH:19][C:13]=2[N:12]=1)C)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:21][O:20][C:16]1[C:14]2[NH:15][C:11]([CH2:10][CH2:9][NH:7][CH3:6])=[N:12][C:13]=2[CH:19]=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178488952HCID 178488952, 화합물

생성물 1

HCID 178483309HCID 178483309, 화합물수율 37.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1.5 g of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-carbamic acid tert.-butyl ester in 10 mL DCM was treated with 0.39 mL of TFA and stirred overnight at rt. The reaction mixture was concentrated in vacuo, redissolved in DCM and treated with diluted NaOH. After separation of the 2 phases the water phase was lyophilized to yield 380 mg of [2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amine as beige solid.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. dissolutionredissolved in DCM
  3. additiontreated with diluted NaOH
  4. customAfter separation of the 2 phases the water phase

출처 및 근거

ORD 기록
ord-9d1d1ccde96d430e95a9e09857093f57
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202885B2

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