Methanol → HCID 20079668, 화합물
반응식
[F:1][CH:2]([F:12])[C:3]1[S:7][C:6]([C:8](OC)=[O:9])=[CH:5][CH:4]=1.CO.[BH4-].[Na+]>C1COCC1>[F:1][CH:2]([F:12])[C:3]1[S:7][C:6]([CH2:8][OH:9])=[CH:5][CH:4]=1참가 물질
5
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of methyl 5-(difluoromethyl)thiophene-2-carboxylate (2.23 g) in THF (60 ml)-MeOH (15 ml) was added NaBH4 (2.20 g) at room temperature, and the reaction mixture was stirred at 60° C. for 1 h. The reaction mixture was quenched with saturated aqueous NH4Cl solution, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (1.94 g) as a pale yellow oil.
후처리
- customThe reaction mixture was quenched with saturated aqueous NH4Cl solution
- extractionextracted with EtOAc
- washThe extract was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
- custompurified by silica gel column chromatography (hexane/EtOAc)
출처 및 근거
- ORD 기록
- ord-d63bc354b72d4b229efa01715e85bb3b
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09365540B2
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