Dimethylformamide → Methyl 5-iodothiophene-3-carboxylate
반응식
[I:1][C:2]1[S:6][CH:5]=[C:4]([C:7]([OH:9])=[O:8])[CH:3]=1.IC.[C:12](=O)([O-])[O-].[K+].[K+].CN(C=O)C>O>[I:1][C:2]1[S:6][CH:5]=[C:4]([C:7]([O:9][CH3:12])=[O:8])[CH:3]=1참가 물질
6
실험 절차
A mixture of 5-iodothiophene-3-carboxylic acid (3.48 g), iodomethane (2.92 g), potassium carbonate (2.84 g) and DMF (35 ml) was stirred at room temperature for 1 day. The reaction mixture was poured into water, and extracted with EtOAc. The extract was washed with brine, dried over MgSO4, concentrated and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (3.62 g) as a white solid.
후처리
- extractionextracted with EtOAc
- washThe extract was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
- custompurified by silica gel column chromatography (hexane/EtOAc)
출처 및 근거
- ORD 기록
- ord-ccf7f8e582f54e4aa7d164c2a6422781
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09365540B2
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