Sodium borohydride → 2-Thiazolemethanol, 4-(difluoromethyl)-
반응식
[F:1][CH:2]([F:13])[C:3]1[N:4]=[C:5]([C:8](OCC)=[O:9])[S:6][CH:7]=1.[BH4-].[Na+]>CO>[F:1][CH:2]([F:13])[C:3]1[N:4]=[C:5]([CH2:8][OH:9])[S:6][CH:7]=1참가 물질
4
실험 절차
To a solution of ethyl 4-(difluoromethyl)-1,3-thiazole-2-carboxylate (900 mg) in MeOH (15 ml) was added NaBH4 (329 mg), and the mixture was stirred at room temperature for 2 h. The mixture was partitioned between saturated NH4Cl solution and EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo to give the title compound (703 mg) as a colorless oil.
후처리
- customThe mixture was partitioned between saturated NH4Cl solution and EtOAc
- washThe organic layer was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-cbb5073800864f14a8eaed68c6c1d4f9
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09365540B2
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