Hydrochloric Acid → (S)-tert-butyl 2-(2-aminobutoxy)acetate

HRID 2204987노트

반응식

HRID 2204987 반응식
C(OC([NH:8][C@@H:9]([CH2:20][CH3:21])[CH2:10][O:11][CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=O)(C)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[NH2:8][C@@H:9]([CH2:20][CH3:21])[CH2:10][O:11][CH2:12][C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14]

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 312751,4-Dioxane2회HCID 86678281(S)-tert-butyl 2-(2-(tert-butoxycarbonylamino)butoxy)acetate

생성물 1

HCID 87385354(S)-tert-butyl 2-(2-aminobutoxy)acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (S)-tert-butyl 2-(2-(tert-butoxycarbonylamino)butoxy)acetate (1 eq, from the previous step) in DCM (0.4 M) at room temperature was added a solution of 4 M HCl in dioxane (10 eq). The reaction was stirred for 2 hours, at which time more 4 M HCl in dioxane (3 eq) was added and stirred for 1 hour. The reaction mixture was concentrated en vaccuo to give the product as an oil. The material was carried onto the next step without further purification.

후처리

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated en vaccuo

출처 및 근거

ORD 기록
ord-29982f93124d4af4997245f0abfa0b43
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09365506B2

반응 노트

불러오는 중…