Hydrochloric Acid → Benzyl 6-aminohexanoate hydrochloride
반응식
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])=O)(C)(C)C.[ClH:24].O1CCOCC1>C(Cl)Cl>[ClH:24].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15]참가 물질
5
실험 절차
To a solution of benzyl 6-(tert-butoxycarbonylamino)hexanoate (1 eq) in DCM (0.17 M) was added 4M HCl in dioxane (30 eq). The resulting mixture was stirred at room temperature for 1 hour. The mixture was concentrated en vaccuo. The crude material was dissolved in DCM and precipitated in diethyl ether to give the product as a white solid.
후처리
- concentrationThe mixture was concentrated en vaccuo
- dissolutionThe crude material was dissolved in DCM
- customprecipitated in diethyl ether
출처 및 근거
- ORD 기록
- ord-677ce6968d8f45078bd719c52386bec1
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09365506B2
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