Acetic Acid → 2-chloro-8-methyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one

HRID 220611

반응식

HRID 220611 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH2:9])[CH:3]=1.[Cl:10][C:11]1[CH:12]=C[CH:14]=[C:15]2NC(=O)OC(=O)[C:16]=12.[C:23]([OH:26])(=O)[CH3:24]>>[Cl:10][C:11]1[CH:16]=[CH:15][C:14]2[NH:8][C:5]3[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][C:4]=3[NH:9][C:23](=[O:26])[C:24]=2[CH:12]=1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 103323,4-DiaminotolueneHCID 6390585-chloro-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione

생성물 1

HCID 687182192-chloro-8-methyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one

반응 조건

온도
110 °C

실험 절차

A mixture of 4-methyl-1,2-phenylenediamine (0.1 mol) and 6-chloro isatoic anhydride (0.1 mol) in acetic acid (85%) was heated at 110° C. for 2 hrs. The mixture was poured into ice-cold water and 2-chloro-8-methyl-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one was isolated (93%) after neutralisation and filtration.

후처리

  1. additionThe mixture was poured into ice-cold water

출처 및 근거

ORD 기록
ord-54cc76e55d0f4c9294ad4d59f0331240
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202989B2

연결된 노트

불러오는 중…