Hydrazine hydrate (1:1) → 4-chloro-1H-pyrazolo[4,3-c]pyridine
반응식
[Cl:1][C:2]1[C:7]([CH:8]=O)=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>COCCOC>[Cl:1][C:2]1[C:7]2[CH:8]=[N:12][NH:13][C:6]=2[CH:5]=[CH:4][N:3]=1참가 물질
4
반응 조건
- 온도
- 75 °C
실험 절차
To a solution of 2,4-dichloropyridine-3-carbaldehyde (7.0 g) in DME (70 mL) was added hydrazine monohydrate (8.0 g) at room temperature. The reaction mixture was stirred overnight at 75° C., and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (4.0 g).
후처리
- concentrationconcentrated under reduced pressure
- customThe residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether)
출처 및 근거
- ORD 기록
- ord-7f68ff6a687a4beabe077440bd05a565
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09371320B2
반응 노트
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