Iodine → HCID 178478341, 화합물
반응식
[Cl:1][C:2]1[C:7]2[CH:8]=[N:9][NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1.[OH-].[K+].[I:13]I.S([O-])([O-])(=O)=S.[Na+].[Na+]>COCCOC>[Cl:1][C:2]1[C:7]2[C:8]([I:13])=[N:9][NH:10][C:6]=2[CH:5]=[CH:4][N:3]=1참가 물질
6
반응 조건
- 온도
- 75 °C
실험 절차
To a mixture of 4-chloro-1H-pyrazolo[4,3-c]pyridine (4.0 g) and potassium hydroxide (4.4 g) in DME (50 mL) was added iodine (13.3 g) at room temperature. The reaction mixture was stirred at 75° C. for 4 hr. The reaction mixture was added to aqueous sodium thiosulfate solution, and the mixture was left stand overnight, and the resulting solid was collected by filtration to give the title compound (6.3 g).
후처리
- waitthe mixture was left stand overnight
- filtrationthe resulting solid was collected by filtration
출처 및 근거
- ORD 기록
- ord-5e0d89dc4c6544d79511c505d2dcf26b
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09371320B2
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