Phosphorus tribromide → 1-(1-Bromoethyl)-3-methylbenzene

HRID 2206542

반응식

HRID 2206542 반응식
P(Br)(Br)[Br:2].[C:5]1([CH3:14])[CH:10]=[CH:9][CH:8]=[C:7]([CH:11](O)[CH3:12])[CH:6]=1>>[Br:2][CH:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([CH3:14])[CH:6]=1)[CH3:12]

참가 물질

3

반응물 2

HCID 24614Phosphorus tribromideHCID 1109521-(3-Methylphenyl)ethanol

생성물 1

HCID 230009161-(1-Bromoethyl)-3-methylbenzene수율 91.3%

실험 절차

Phosphorus tribromide (4.28 g, 15.9 mmol) was added drop-wise to a stirred neat solution of 1-(m-tolyl)ethanol (0.9 g, 6.6 mmol) at 0° C. After being stirred to room temperature over 12 h, the reaction was carefully quenched with sat'd saturated aqueous NaHCO3 solution and the mixture was extracted with EtOAc. The organic extract was washed with water, dried with MgSO4, and conc. in vacuo to afford the title compound (1.2 g, 91%) as a colorless oil, that was used directly in the next step without further purification. LCMS 200 (M+H+).

후처리

  1. customthe reaction was carefully quenched with sat'd saturated aqueous NaHCO3 solution
  2. extractionthe mixture was extracted with EtOAc
  3. extractionThe organic extract
  4. washwas washed with water
  5. dry with materialdried with MgSO4

출처 및 근거

ORD 기록
ord-c35aa29ec8ad4d20905cedd6519d2cca
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09371331B2

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