Potassium Iodide → Glycine, N-(2,2-difluoroethyl)-, ethyl ester
반응식
[F:1][CH:2]([F:5])[CH2:3][NH2:4].Br[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[I-].[K+].C(N(C(C)C)CC)(C)C>C(#N)C>[F:1][CH:2]([F:5])[CH2:3][NH:4][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9]참가 물질
6
실험 절차
2,2-difluoroethylamine (4.0 g) was added to a suspension of ethyl bromoacetate (5.4 mL), potassium iodide (0.82 g), diisopropylethylamine (9.8 mL) in acetonitrile (100 mL) and the mixture was stirred at RT for 25 h. The mixture was concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to afford the sub-title compound (7.0 g) as a colorless oil; 1H NMR (300 MHz, CDCl3); 5.82 (1H, tt), 4.18 (2H, q), 3.46 (2H, s), 3.00 (2H, dt), 1.26 (3H, t).
후처리
- concentrationThe mixture was concentrated under reduced pressure
- customThe residue was purified by flash column chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-b053c74e468b4549b3254fe9cae52beb
- 출처 데이터셋
- uspto-grants-2016_06
- 특허 번호
- US09376398B2
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