Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium borohydride → 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-one | HCID 46941396 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-Methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-ol | HCID 46856399 | — |
반응 단계
Sodium borohydride (2.8 g, 0.074 mol) was added portionwise to a solution of 4-methyl-1-[4-(trifluoromethyl)phenyl]pentan-1-one [Intermediate 1; Step 1] in EtOH (50 mL) cooled in ice. When addition was complete (30 min) the mixture was stirred at RT for 1 h then quenched with NH4Cl solution (50 mL) followed by 2N HCl (20 mL). Extraction with ether (3×50 mL) followed by drying (MgSO4) and concentration of the organic phase gave 4-methyl-1-(4-(trifluoromethyl)phenyl)pentan-1-ol as a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08203004B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-6ae252e3dcf8477faafa09aaac013c5b |
| 출처 메모 | uspto-grants-2012_06 |