Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → (2S,3S)-3-(t-Butyldimethylsilyloxy)-2-methylhexanal
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | tert-Butyldimethylsilyl trifluoromethanesulphonate | HCID 123564 | — |
| 반응물 | (2R,3S)-2-Methyl-3-propyloxiranemethanol | HCID 10931464 | — |
| 반응물 | (2R,3R)-3-[t-Butyldimethylsilyloxy)-2-methylhexanal | HCID 14959487 | — |
| 생성물 | (2S,3S)-3-(t-Butyldimethylsilyloxy)-2-methylhexanal | HCID 10879364 | — |
반응 단계
Epoxy alcohol 13, 1.25 eq TBSOTf, and 1.30 eq DIPEA were reacted as in the preparation of 16 to give the crude aldehyde 14 in 95% +yield. 1H NMR, 13C NMR, IR, and high resolution MS are identical to 16. [δ]D=+19.3° (c=1.10, CH2Cl2). 1H NMR integration of δ 9.67 and the contaminating diastereromer at δ 9.71 indicated a >50:1 ratio.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05426206 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-5cf56b8424ec43e3b8980dfd92998226 |
| 출처 메모 | uspto-grants-1995_06 |