Sodium Hydroxide → 4-((((Tert-butoxy)carbonyl)amino)methyl)-3-fluorobenzoic acid

HRID 220772노트

반응식

HRID 220772 반응식
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[C:6]([F:19])[CH:5]=1.[OH-].[Na+]>O1CCOCC1.CCOC(C)=O>[C:15]([O:14][C:12]([NH:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:20])=[O:2])=[CH:5][C:6]=1[F:19])=[O:13])([CH3:18])([CH3:16])[CH3:17]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 597677014-(tert-Butoxycarbonylamino-methyl)-3-fluorobenzoic Acid Methyl Ester

생성물 1

HCID 230231654-((((Tert-butoxy)carbonyl)amino)methyl)-3-fluorobenzoic acid수율 100.4%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of 4-(tert-butoxycarbonylamino-methyl)-3-fluorobenzoic acid methyl ester from Example E3.5 (640 mg, 2.25 mmol) in dioxan (40 ml) was added 1N NaOH (4.5 ml, 4.5 mmol). The mixture was stirred for 18 h, diluted with EtOAc, washed with 1N KHSO4, water and brine and concentrated in vacuo to give a white solid identified as the title compound (608 mg, 100%).

후처리

  1. washwashed with 1N KHSO4, water and brine
  2. concentrationconcentrated in vacuo
  3. customto give a white solid

출처 및 근거

ORD 기록
ord-55e658be137d45bfb84319c930d0d0ac
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202858B2

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