Tetrahydrofuran → HCID 608124, 화합물

HRID 2207725노트

반응식

HRID 2207725 반응식
[C:1]([NH:4][CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[NH:9][C:8]=1[C:18]([O:20]CC)=[O:19])(=[O:3])[CH3:2].O1CCCC1.[OH-].[Na+]>C(O)C>[C:1]([NH:4][CH2:5][CH2:6][C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[NH:9][C:8]=1[C:18]([OH:20])=[O:19])(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 44581689HCID 44581689, 화합물

생성물 1

HCID 608124HCID 608124, 화합물수율 94.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a mixture of ethyl 3-(2-acetamidoethyl)-5-methoxy-1H-indole-2-carboxylate (350 mg), tetrahydrofuran (5.00 mL), and ethanol (5.00 mL) was added a 1 M aqueous sodium hydroxide solution (2.00 mL), followed by stirring at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the obtained residue was dissolved in water and adjusted to be weakly acidic by the addition of 1 M hydrochloric acid. The precipitated solid was collected by filtration and then dried to obtain 3-(2-acetamidoethyl)-5-methoxy-1H-indole-2-carboxylic acid (300 mg) as a gray solid.

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe obtained residue was dissolved in water
  3. additionto be weakly acidic by the addition of 1 M hydrochloric acid
  4. filtrationThe precipitated solid was collected by filtration
  5. customdried

출처 및 근거

ORD 기록
ord-82960498a49d41c9b6ad5dce80fb6542
출처 데이터셋
uspto-grants-2016_06
특허 번호
US09376449B2

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