Ethanol → Ethyl 3-fluoro-4-hydroxybenzoate

HRID 220817

반응식

HRID 220817 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[OH:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[CH2:17]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([OH:11])=[C:2]([F:1])[CH:3]=1)[CH3:18]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 1604563-Fluoro-4-hydroxybenzoic acid

생성물 1

HCID 13745619Ethyl 3-fluoro-4-hydroxybenzoate수율 85%

실험 절차

A solution of 3-fluoro-4-hydroxy-benzoic acid (5.16 g, 33.1 mmol) in ethanol (100 ml) was treated with conc. sulphuric acid (5 ml), and the mixture heated at reflux for 4 days. The volatiles were removed in vacuo, and the aqueous residue was basified with saturated NaHCO3 and extracted twice with diethyl ether. The combined organic extracts were dried and concentrated in vacuo to yield the title compound (5.16 g, 85%).

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 4 days
  3. customThe volatiles were removed in vacuo
  4. extractionextracted twice with diethyl ether
  5. customThe combined organic extracts were dried
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9c84b9f0d9cf4aa3ae0ff39ecb8f6250
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08202858B2

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